NEUROSCI 223 Study Guide - Midterm Guide: Ligand-Gated Ion Channel, Reuptake, Clathrin
7 Apr 2016
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Bio/neuro 223_spring2016 key concepts lectures 11-13 (synaptic transmission & Plasticity: be able to draw the steps and major players in the synaptic vesicle cycle. When ligand binds pore opens and allows ions to flow through. Act as ion channels to cause depolarization or hyperpolarization. Structure: gpcrs (7 tm proteins). machrs + gpcrs. Function: larger effects rather than short term opening of channels. Allows the organization of the postsynaptic membrane. The psd has been proposed to concentrate and organize neurotransmitter receptors in the synaptic cleft. 7 it can activate nmda or ampa receptors. How would you show, experimentally, that it was due to - the mechanism above? (hint: how would you show it, move it, and/or block it?) Show it: repeatedly stimulate the pre synaptic neuron and measure the post synaptic response and see if it is larger after the tetanus. Ca2+ is responsible for signaling vesciles to exocytose.
