CAS BI 203 Study Guide - Quiz Guide: Cholera Toxin, César Díaz, Cyclic Adenosine Monophosphate
18 Jan 2018
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Cholera in haiti: explain the rationale for the mspp recommendations in terms of the transmission mechanism(s) for cholera. Cholera is transmitted through contaminated food or water. The membrane receptor for the cholera toxin is located inside the intestine, on the intestinal epithelial: the cholera bacteria produce a toxin that is made of six protein subunits. The epithelial cells have special carbohydrate receptors on the cell surface membrane the toxins are specific to the shape of the receptors on the membrane. When the toxins bind to the receptors, the toxic part of the toxins enter the cells and activate cyclic amp (messenger molecule). +vomiting/diahhera because of increased water in small intestine. ) Hydrolysis of gtp by the g-alpha usually serves as an inhibitor for a reaction that is gtp dependent. Cholera toxin causes a chemical modification that prevents gtp hydrolysis and leads to unregulated signaling.
