NUR 311 Study Guide - Quiz Guide: Postmarketing Surveillance, Bronchospasm, Pharmacokinetics
Document Summary
Pharmacological clinical judgement, safety, & terminology 8 questions. Phase i investigational new drug (healthy volunteers) Assesses: drug metabolism, pharmacokinetics, biological effects (c/c humans to animals) Phase ii-iii small number of patients, short duration. Postmarketing surveillance of effects (most side effects are found here ) Adr noxious, unintended, undesired effect that occurs at normal drug dose. [ranges from mild (nausea, itchy) to severe (respiratory depression, etc)] Side effects nearly unavoidable, produced at normal doses. Dose dependent intensity (higher dose, more side effects) Allergic reactions triggered by an immune response (<10% adr) Mild itchy // severe anaphylaxis, bronchospasm. Severity dependent on the degree of sensitization. Idiosyncratic effect response due to genetics (uncommon) G6pd (africans) : aspirin causes rbc hemolysis. Slower inactivation of drugs (drug effects last longer) Paradoxical effect opposite of expected reaction. Iatrogenic disease disease produced by a provider or drug. Physical dependence body"s adaptation to drug exposure. Antipsychotic medication causes symptoms similar to parkinsons.
