Pharmacology 2060A/B Study Guide - Final Guide: Neurofibrillary Tangle, Substantia Nigra, Sympathetic Nervous System
16 Apr 2016
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Increased blood pressure (bp = co x pr: increased cardiac output: heart rate, heart contractility, blood volume, venous return, increased peripheral resistance: arteriolar constriction. Do not take with ace inhibitors : alcohol and smoking = increased blood pressure. Hypokalemia = potassium deficiency (hyper = surplus) Hyponatremia = sodium deficiency (hyper = surplus) Progressive dementia, memory loss, issues with problem solving, judgement, behaviour and intelligence. Decreased cholinergic nerve function and degeneration of neurons in cerebral cortex. Neuritic plaques and neurofibrillary tangles in brain. Excess glutamate release; glutamate dissociates magnesium from nmda receptors, allowing excess calcium intake excess calcium entering the cell; calcium causes degradation of neurons and memory/learning impairment. Difficulty telling between fiction and reality; hard time acting normal, think logically, have normal emotions. Increased dopaminergic nerve function: pd treatment can cause schizophrenia-like symptoms. Increased 5-ht1a and decreased 5-ht2a receptors in frontal cortex. Decreased number of nmda receptors in regions of brain.
