Pharmacology 2060A/B Study Guide - Final Guide: Nmda Receptor Antagonist, Sodium Channel Blocker, Apolipoprotein B
16 Apr 2016
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Cholesterol transferred from non-hepatic tissue to the liver. Delivers triglycerides from liver to adipose tissue & muscle. Inhibit hmg-coa reductase (which is involved in rate-limiting step); causes upregulation of hepatic ldl receptors. +ve molecule that binds to ve bile acid; Inhibit npc1l1 intestinal uptake transporter of dietary cholesterol; example: ezetimibe. Converts inactive angiotensin i to active angiotensin ii. Potent vasoconstrictor (binds to at1 receptor); stimulates release of aldosterone and adh/vasopressin. Block sodium and chloride ion reabsorption; promotes excretion of water and ions as water remains in tubules due to osmotic pressure. Block absorption of na+ and cl- in ascending limb in the loop of henle. Block absorption of na+ and cl- in distal tubule; most common treatment of hypertension. Liver then removes more cholesterol from blood; do not use for pregnant women. Makes liver produce more bile acid; this requires ldl cholesterol increased uptake of ldl in liver results. Most effective drug for lowering plasma triglyceride levels.
