Biology 3593B Study Guide - Quiz Guide: Focal Adhesion, Cell Adhesion Molecule, Cell Adhesion
Document Summary
Cell adhesion: properties of surface membrane determines cell adhesion, affinities of cells to each other can be different, selective affinity. If a-b connection is greater than a-a and b-b connection the aggregate will remain mixed. If a-b connection is lower, a and b form separate aggregates. If a-a connections is greater than b-b connection, a will become central: during developmental processes strength of adhesion must change, strength of cell adhesion strongly depends on expression od cadherins. = calcium dependent adhesion molecules: transmembrane proteins which interact with cadherins on adjacent cells. Cadherins are most important molecules for cell adhesion. Different subtypes of cadherins crucial for correct morphogenesis. Protocadherins: anchored inside cells by catenins (= anchoring proteins, bound to actin filaments of cytoskeleton, also serve as signal molecules. Transforming growth factor (tgf- ) superfamily: receptor tyrosine kinase (rtk) is typical receptor for paracrine factors (e. g. fgf) Complex signal cascade links receptor to transcription factor.
