Physiology 3140A Lecture Notes - Lecture 4: Proximal Tubule, Transcellular Transport, Keratin 8
28 Dec 2017
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Heterophilic binding: two molecules that are different that bind to each other. Integrins: bind to ecm and cytoskeleton: heterophilic bindings can be found between two different cells, e. g. selectins (found in platelet aggregation) like to bind sugars and glycoproteins. Homophilic binding: cell-cell contacts where interaction occurs between the same type of molecules. Binding affinity: how much one molecule likes the other, not as strong as antigen-antibody binding. Spatial distribution: the number of binding sites that exist, the more binding proteins come together, the stronger the interaction. Activity state of adhesion molecules: glycosylation, phosphorylation to turn proteins/adhesion molecules on/off, etc. External forces surrounding the cells: sheer stress break bonds by pulling cells apart. The same molecule can have intercellular and lateral binding. Interaction can be increased by both types of binding. Mechanically attach cells to neighboring cells (or ecm) Cell-matrix: hemidesmosomes (integrin + intermediate filaments, focal adhesions (integrin + actin)
