Biochemistry 2280A Study Guide - Final Guide: Rna Editing, Nuclear Pore, Nuclear Membrane

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Chris Brandl

Document Summary

The human genome encodes ~21,000 protein encoding genes. In any cell type less than 10,000 are expressed. The expression of the correct genes is essential for growth and differentiation. Importance of gene expression becomes evident when we realize defects in gene regulation often result in disease. Most notably cancer, result from or are manifest by alterations in expression of one or more genes. By manipulation gene expression profiles, we have the potential to prevent or reverse disease. Most diseases are due to altered expression of one or more genes. By therapeutically manipulating gene expression, we have the potential to prevent or reverse disease. The rna step allows genes to be expressed at different levels. Each gene is present at a constant level, two copies per cell (diploid) Rna can vary from less than one to over 1000 copies per cell. This allows a quick off signal to stop gene expression.