IMM250H1 Study Guide - Innate Immune System, Lectin, Neutrophil
Document Summary
In blood in early phase of immune response. Interleukin 1 and 6 (il-1, il-6) : causes body temperature, inflammation. Clots bvs downstream of injury so infection cannot spread. Blood gets into ecm: allows immune cells to move easily between cells to kill pathogens. Complement: group of blood proteins that recognize and destroy microbes. Overview of the main components and effector actions of complement. In adaptive immune system: classical / humoral pathway. * see fig 2. 26 for list of fxns for all compliment proteins. Products can bind to microbial surfaces (or to antibodies bound to microbes) Inhibited by regulatory proteins found on host cells. Activates phagocytosis of c3b opsonized pathogens bound to complement receptor 1. Causes chemotaxis of macrophages and neutrophils thorugh c5a receptor. With c3a, causes permeability of bvs. C5a + c3a = peptide mediators of inflammation + phagocyte recruitment: permeability of bvs.
