HTHSCI 3I03 Chapter Notes - Chapter 3: Immunoglobulin Superfamily, Cytotoxic T Cell, Adaptive Immune System
24 Mar 2015
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Document Summary
Local inflammation is central to innate immunity and the initiative of adaptive immune responses. Local inflammation is essential to successful vaccination. Inflammation is characterized by redness, heat, swelling, and pain. Important cytokines secreted by macrophages in response to local infection. Production of il-6 (see its effects below) Acute-phase protein production in the liver increases permeability. Thus increases entry into tissues of igg, complement, and cells. Induces differentiation of cd4 t cells into th1 cells (stimulate phagocytosis) Addressins (cams or cell adhesion molecules) involved in leukocyte interactions: Sulfated sialyl-lewisx is an oligosaccharide present on the cell-surface glycoproteins of circulating leukocytes and it is recognized by p- and e-selectin. You already know that neutrophils make up the first wave of cells that cross the blood vessel wall to enter an inflamed tissue. Neutrophils leave the blood and migrate to sites of infection in a multi-step process involving adhesive interactions that are regulated by macrophage-derived cytokines and chemokines.
