BIO200H5 Study Guide - Partition Coefficient, Ionic Compound, Acid Strength
Document Summary
Ability of molecules to dissolve from one phase to another. O attracts better than h can be added to the non-binding parts of the drug molecule. This will increase the solubility without disturbing the drug effect. No attraction b/w drug molecule and the lipid molecule. They are forced into lipid membranes by moving out water lattices. Branches tend to make the molecule more water soluble. Concentration in water is higher than it is in fat. Both basic and acidic group parts - one will dominate over the other. ex. Lectures page 7 pka - half ionic and half non-ionic form of an ionic compound ph - experimental number. At pka, drug will be half charged and half uncharged. As we move to more acidic medium, molecule will become more and more uncharged. Binding of drug to receptor is weak and transient. We don"t see strong covalent binding - this is normally in activated enzymes.
