HLSC 2110U Study Guide - Midterm Guide: Adrenal Medulla, Porphyria, Heme
24 Apr 2019
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Document Summary
Serve as building blocks for proteins, amino acids, and nitrogen containing compounds with important functions in the body. Cyclic compounds that bind metal ions usually iron. Heme is prosthetic group for hemoglobin, myoglobin, cytochromes, catalase, tryptophan pyrrolase. Diseases caused by a build up of porphyrins. Deficiency of enzymes that are responsible for heme biosynthesis. Triggers increase the demand for heme, deficient enzyme is unable to keep up with the demand. Triggers can include drugs, sunlight, stress, smoking, dieting. Acute affects ns dehydration, breathing issues, seizures. Cutaneous affects skin sensitivity to sunlight, redness, blisters. Most common treatment is to avoid the triggers, high carb diets. Dopamine and norepi are nt in the brain and ans. Norepi and epi are synthesized in the adrenal medulla. Outside ns, norepi and epi act as regulators of carb and fat metabolism. Released from storage vesicles in the adrenal medulla in response to fright, exercise, cold, and low blood sugar.
