BCHM 102 Lecture Notes - Lecture 20: Antihistamine, Glucuronic Acid, Glucuronosyltransferase
2 Dec 2016
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Lecture twenty - specialized products of amino acids. Lecture objectives: understand the importance of amino acids in the synthesis of products other than protein, porphyrins heme. Consequences of defects: other nitrogen containing compounds: Amino acids are precursors in the synthesis of: porphyrins, hormones, neurotransmitters, purines, pyrimidines. All of these are n-containing compounds with important physiological functions. Simultaneous synthesis and degradation of the porphyrin ring and recycling of fe is coordinated with heme protein turnover we have to synthesize new heme with every new hemoglobin. Heme: protoporphyrin ring + fe2+ heme protein: porphyrin ring + fe2+ + protein. If we have a lot of heme, heme synthesis is inhibited: reaction is inhibited by hemin heme (oxidized form of heme, fe2+ replaced by fe3+) Inhibited by lead (blocks formation of heme by inhibiting enzyme ferrochelatase) Absence of heme synthesis causes the accumulation and increased excretion of porphyrins or porphyrin precursors in the urine (causes urine to be red)
