CHEM430 Study Guide - Final Guide: Retinoic Acid Receptor Alpha, Retinoid X Receptor, Thromboxane A2
29 Mar 2016
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Vinblastine inhibits tubulin polymerization binds between alpha and beta tubulin inhibits mitosis (makes up mitotic spindle) and promotes apoptosis cancer chemotherapy. Vancomycin antibacterial inhibits cross linking of bacterial cell wall (same as penicillin but different mechanism) binds terminal of d-alanine dipeptide and inhibits transpeptidase reaction. Works on gram positive bacteria only cell surfers osmotic lysis resistance took a while to develop, used to treat mrsa resistant strains change d-alanine-d-alanine peptide to d-alanine-d- lactate: possible solution is vancomycin derivative with amidine group. Valinomycin potassium ionophore inserts itself in cell membrane and makes permeable permeabilizes pro and eukaryotic cells experimental (research) not clinical. Urokinase protein molecule dissolve blood clots in stroke or heart attack plasminogen activator cleaves plasminogen to plasmin to dissolve blood blots urokinase can do this too. Gpcr (i think) closes kir channel promotes insulin secretion from beta cells closing kir channels increases the membrane potential calcium- mediated insulin release.
