BIOL341 Study Guide - Midterm Guide: Immunoglobulin Superfamily, Immunoglobulin Class Switching, Immunoglobulin Domain
21 Mar 2017
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Document Summary
Receptor ligand interactions: adaptive immune receptors located on plasma membrane, bind ligands through non-covalent bonds with close fit, generally single lymphocyte expresses only one type of antigen receptor, can be many signaling receptors. Antigen binding: antigen: substance bound by antibody or tcr generally a protein bound by a recombining receptor. The smaller the number, thr stronger the binding: reversible process with weak binding so it needs to last a while and have numbers to activate cells, polyvalent or multivalent antigens: multiple repeated binding sites epitopes. Apcs have more than 1 molecule of each mhc allele on the surface: avidity: overall strength of attachment based on # of binding sites. Immunogen: molecules that simulate immune responses possible for small molecules to be antigens but not immunogens: hapten: small molecule (antigen) linked to carrier to make it immunogenic. Types of epitopes: linear epitope: formed by several adjacent amino acids (6)
