PATH 3610 Study Guide - Midterm Guide: Benign Tumor, Carcinogenesis, Sexually Transmitted Infection

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tealarmadillo260

28 Jun 2017

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- viremia can induce a systemic inflammatory response (cytokine spill over into blood) Transplacental (vertical transmission) from mother to fetus through the placenta. ~ vs. horizontal transmission - infection spread through siting beside someone. In the crimean war estimated that more soldiers in war died from disease than from the actually fighting and their wounds. Used to be the side that won the war was the healthy side. Some principles ~ politics play a major role in definitions. Rotavirus infection of children rotavirus infection cause diarrhea and vomiting. = all children infected in first 4 years, infectious && contagious. **infection does not mean diseased - can be infected but show no signs of disease (ex. Incidence: 25% per year (new cases in a given population in a given time period (usually a year)) Prevalence at 4 years = 100% (# of individuals total that have been affected by age 4)

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Provides substantial and thoughtful response, reflection â in-depth and detailed for the following post. Please don't copy past from the web

Yellow Fever â Another Reason to Hate Mosquitos

Out of the blue one day you begin to run a fever. The fever expands into loss of appetite and vomiting. A few days later, the vomiting continues and you develop jaundice; you even begin to bleed from your mouth, nose, and eyes. Eventually you die. This is the experience of 7% of the individuals who are infected by Yellow Fever (WHO, 2017).

Yellow Fever is a preventable disease that is spread through mosquitos. The disease has the potential to kill its victim (WHO, 2017). It has an inexpensive vaccine that provides a lifelong immunity to the disease (WHO - French Guiana). As of 2016, there have been reported outbreaks of Yellow Fever in six countries; three in Africa, and three in South America (Yellow Fever in Africa and the Americas, 2016).

According to the World Health Organization, Yellow Fever is spread through mosquitos. A mosquito bites an infected carrier (either a person or monkey). The same mosquito then bites an uninfected person or monkey and spreads the disease to that individual. Yellow Fever will incubate in the new carrier for three to six days before symptoms begin to show. The symptoms begin as body aches, fever, nausea and vomiting. It is at this point that the disease is often misdiagnosed as other illnesses and diseases such as poisoning, malaria, hepatitis, etc. Within another three to four days, most patients improve. However, 15% of infected patients will progress to a second stage of symptoms that are much more severe. This stage exhibits symptoms such as jaundice, continued vomiting, and even bleeding out of the mouth, nose, and eyes. The patientâs kidney functions deteriorate and half of these patients will even die (WHO, 2017).

Thankfully, there is a vaccine for Yellow Fever. The vaccine requires ten days to become affective and it will last the entire life span of the patient. The only issue is getting the vaccine to the affected areas and raising awareness of the disease and the vaccine to the population in that area (WHO - French Guiana).

A 2017 report in the Weekly Epidemiological Record, says that in 2016, the world saw six countries where there was a Yellow Fever outbreak. The three African countries where the outbreak occurred are Angola, Uganda, and the Democratic Republic of the Congo. Africa had 130 confirmed deaths from Yellow Fever as a result of that outbreak. The death rate was 13.4% of the confirmed cases; this is about double the expected death rate (Yellow Fever in Africa and the Americas, 2016). This high death rate might be attributed to the poor sanitation and lack of access to medical treatment in those areas. According to the World Health Organization, the only way to treat Yellow Fever is with hydration, antibiotics, and supportive care for respiratory failure (WHO, 2017). These treatments are likely less common in East-Central African countries.

The other three countries listed in the 2017 report were in South America. These countries are Brazil, Columbia, and Peru. There were less cases of Yellow Fever in these countries when compared with Africa, but the death rate was a shocking 28.2% (Yellow Fever in Africa and the Americas, 2016)! The same reasons for the high death rate likely apply to these countries as well (poor sanitation and lack of access to medical treatment).

Yellow Fever is a preventable disease that has a simple method of exposure. Most of its victims do not die, and it is currently limited to countries where the mosquito population is less controlled and there is limited access to medical treatment. The World Health Organizations advice is to limit travel to countries where a Yellow Fever outbreak has occurred, but if a person does travel there, they should receive the vaccine ten days prior to their travel. Additionally, the World Health Organization stresses limiting exposure to mosquitos. The World Health Organization proposes that the citizens in these areas should be educated on the disease and its vaccine (WHO - French Guiana). By following these instructions, Yellow Fever should likely be contained to a few countries throughout the world, and possibly even eradicated one day.

References:

Yellow Fever in Africa and the Americas, 2016. Weekly Epidemiological Record, 32, 442-452. Retrieved fromhttp://web.b.ebscohost.com.proxy195.nclive.org/ehost/pdfviewer/pdfviewer?vid=2&sid=1b24418c-8c06-466d-8578-4bd75e665959%40sessionmgr104

World Health Organization (August 30, 2017). Yellow Fever âFrance-French Guiana. Retrieved from http://www.who.int/csr/don/30-august-2017-yellow-fever-french-guiana/en/

World Health Organization. Yellow Fever. Retrieved from http://www.who.int/csr/disease/yellowfev/en/

violetdinosaur513

Provides substantial and thoughtful response, reflection â in-depth and detailed for the following post. Please don't copy past from the web

Tetanus; infamously known as lockjaw. This disease is found worldwide. Non-communicable diseases that will literally make your muscles tighten. Tetanus is not your typical disease. It is not spread person to person but through scraps, cuts, or any open wounds that break the skin. The incubation period for the disease is anywhere from 3-21 days depending on the wound and how contaminated the object was. The bacterium enters through these wounds and attacks the body affecting mostly the muscles. Most cases occur in people who are not vaccinated or do not maintain their boosters. Boosters are needed every ten years to prevent the disease. Although we cannot prevent injuries that cause the body harm we can prevent the disease from affecting our bodies through vaccination administration.

Tetanus cannot be tested but is diagnosed by physical examination conducted by a licensed physician. The diagnosis is based off physical examination and the reports from the patients about the symptoms they are experiencing. Some of those symptoms include; seizures, body aches, muscle spasms, jaw cramping, difficulty swallowing, headaches, fever, sweating, changes in blood pressure, and changes in their heart rate. Other complications can develop depending on a person's individual health and health history.

The best way to prevent Tetanus is by preventing it with the Tetanus vaccination and the boosters that are needed every ten years. This vaccination could be administered by a number of ways. There are four different types of combinations that include the Tetanus vaccination; Diphtherias & Tetanus (DT), Diphtherias, Tetanus, & Pertussis (DTaP), Tetanus & Diphtherias (Td), and Tetanus, Diphtherias, & Pertussis (Tdap).Tetanus is administered at six weeks old, ten weeks old, and fourteen weeks old. Boosters are given three different times during childhood to keep the children up to date on vaccinations that prevent the disease. People affected by Tetanus are not immune to getting Tetanus again like some other known diseases.

According to the CDC (Center for Disease Control) in their article about Tetanus they reported that Tetanus cases have been on the decline by more than 95% because of the increase in vaccinations being distributed worldwide. The CDC also reported that deaths in the United States are on the decline and have declined more than 99%. According to WHO (World Health Organization) in 2016 there are only 13, 502 reported cases globally. They also reported that 86% of the world is covered by the Tetanus vaccination. According to the World Health Organization there are currently 8 countries in the world that have 50% of their population affected by Tetanus. The other 50% are reported to have received their Tetanus vaccination. Majority of those countries are found in the middle of Africa. There are currently 27 countries in the world that 50-79% of their population who have received their vaccinations. There are also 130 countries that have over 90% of their population who have been vaccinated.

Tetanus is a vaccine preventable disease in which everyone can be affected by. Vaccinations are currently a controversial topic everywhere. Vaccinations play an important role in helping prevent disease like Tetanus.

References:

1. About Tetanus. (article). Retrieved September 1, 2017 from https://www.cdc.gov/tetanus/about/index.html

2. Tetanus. (article). Retrieved August 30, 2017 from www.who.int/immunization/diseases/tetanus/en/

silverraven404

Highlight or bold the answer you select for multiple choice or type in your answer in the blank space provided.

1. Which of the following is not true of the nervous system?

Consists of central and peripheral systems

(b) Central nervous system is composed of brain and spinal cord

(d) Meninges are membranes that cover brain and spinal cord

(e) Normally free of microbes

2. Which of the following is a common cause of meningitis in nonimmunized young children?

(a) Streptococcus pneumoniae

(b) Escherichia coli

(d) Haemophilus influenzae

(e) None of the above

3. A complication of infection with this organism (Waterhouse-Friderichsen syndrome) can occur if the organism becomes widely distributed in the body, leading to endotoxin shock and death. The organism is:

(a) Haemophilus influenzae type A

(b) Neisseria meningitidis

(d) Streptococcus pneumoniae

(e) Listeria monocytogenes

4. Which of the following bacterial meningitis diseases currently is the most common type in the U.S., with increased incidences in infants and in the 15- to 24-year-old age group, and has three types or strains of the infectious microbe?

(a) Haemophilus meningitis

(b) Listeriosis

(d) Meningococcal meningitis

(e) a and c

5. Before development of a vaccine against this microbe, the disease it caused accounted for two-thirds of bacterial meningitis cases during the first year of life but is still the number one leading cause of mental retardation in patients who survive serious disease due to permanent central nervous system disorders. What is the microorganism?

(a) Haemophilus influenzae type B

(b) Haemophilus influenzae type A

(d) Streptococcus pneumoniae

(e) Listeria monocytogenes

6. Which of the following bacteria that may cause meningitis is Gram-positive and therefore does not cause endotoxin shock in infected individuals?

(a) Escherichia coli

(b) Neisseria meningitidis

(d) Haemophilus influenzae type B

(e) None of these

7. Avid swimmers and hot tub enthusiasts sometimes acquire an opportunistic infection caused by Naegleria fowleri that results in a meningoencephalitis. This organism is a (an):

(a) Protist

(b) Helminth

(d) Amoeba

(e) a and d

8. Which of the following in NOT true about listeriosis?

(a) Foodborne transmission is the most common source of infection.

(b) It is a leading cause of bacterial meningitis today.

(d) It is sometimes acquired as a zoonosis.

(e) Individuals with impaired immune systems are highly susceptible to this disease.

9. Viral meningitis is usually always fatal if untreated, unlike bacterial meningitis, which is always self-limiting and nonfatal. True or false?

10. Which of the following is acid-fast and causes Hansen's disease?

(a) Mycobacterium tuberculosis

(b) Clostridium tetani

(d) Haemophilus influenzae

(e) Mycobacterium leprae

11. An immunofluorescent antibody test (IFAT) has replaced the older test for the presence of inclusions in neurons (Negri bodies) for the detection of infections caused by:

(a) Neisseria meningitidis

(b) Enteroviruses

(d) Rabies virus

(e) Haemophilus influenza

12. The viruses that cause encephalitis are most likely to be:

(a) Togaviruses

(b) Enteroviruses

(d) Rabies virus

(e) Hepatitis viruses

13. What do the following viral encephalitis diseases have in common: eastern equine encephalitis, western equine encephalitis, Venezuelan equine encephalitis, St. Louis encephalitis, West Nile fever?

(a) They are all caused by the same virus.

(b) They are have the horse as a common intermediate host.

(d) Birds are never involved in the life cycle of the viruses that cause these diseases.

(e) Both a and d.

14. The only bacterium known to damage peripheral nerves is:

(a) Naegleria fowleri

(b) Mycobacterium leprae

(d) Neisseria meningitidis

(e) Haemophilus influenzae

15. All of the following are true about Clostridium tetani, the causative agent of tetanus, EXCEPT:

(a) They are spore-forming rods.

(b) They are part of the normal bowel microflora of horses, cattle, and humans.

(d) Their toxin elicits muscle stiffness, spasms, and paralysis in the victim.

(e) They require oxygen to survive.

16. A vaccine that was developed in 1933 has proven effective in reducing the incidence of disease caused by:

(a) Clostridium botulinum

(b) Mycobacterium leprae

(d) Streptococcus pneumoniae

(e) Listeria monocytogenes

17. The most common form of disease caused by Clostridium botulinum is:

(a) Infant

(b) Wound

(d) Foodborne

(e) None of these

18. The endospores of this organism are the most heat-resistant known; it is:

(a) Clostridium tetani

(b) Clostridium botulinum

(d) Streptococcus thermicos

(e) Listeria monocytogenes

19. All of the following are true about Clostridium botulinum, the causative agent of botulism, EXCEPT:

(a) Their ability to form toxin depends on infection with a bacteriophage.

(b) They can produce one of eight different toxins, all of which cause human disease.

(d) Although their endospores are highly heat-resistant, their toxin can be inactivated by only a few minutes' boiling.

(e) All of the above are true.

20. All of the following are true about poliomyelitis EXCEPT:

(a) Most poliovirus infections are inapparent or mild and nonparalytic.

(b) Polio can be caused by three strains of picornaviruses.

(c) The Salk vaccine contains live, attenuated polioviruses while the Sabin vaccine contains formalin-inactivated polioviruses.

(d) Transmission is by the fecal-oral route and pharyngeal secretions.

(e) Poliomyelitis has afflicted man for thousands of years.

graydinosaur157

PATH 3610 Study Guide - Midterm Guide: Benign Tumor, Carcinogenesis, Sexually Transmitted Infection

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