PATH 3610 Lecture Notes - Lecture 9: Adaptive Immune System, Antigen, Tight Junction
21 Feb 2014
School
Department
Course
Professor
Document Summary
These cells are replaced quite rapidly because the cells on the crypt are still intact: viral destruction of the crypt epithelium results in failure of renewal of villus absorptive cells and collapse of the villi. Regeneration is a longer process than after viral infections of villous tip epithelium. Causative agents of gastroenteritis in humans and their general characteristics including genome and virion structure. Rotaviruses: group a rotaviruses are a major cause of epidemic diarrheal disease in children, clinical symptoms: onset is often abrupt, vomiting, watery diarrhea, severe dehydration, fever and abdominal pain occur frequently, malnutrition increases severity of symptoms. Immunity after infection is incomplete, but repeat infections tend to be less severe than the original infection. Characteristics: nonenveloped, tripled layered virus (it is very protected from the stomach enzymes) Icosahedral capsid: genome composed of segmented double-stranded rna, acid resistant, stable in the environment, trypsin facilitates viral infectivity (cleaves vp4 to form vp5 and vp8, whih interact with cellular receptors).
