BIOL 1080 Final: Biol1090 Final Exam Review-2

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Dynamic network of filaments and tubules that extend through the cytosol. Structural polarity is important for mt growth/shrinkage direction of: shrinkage can occur very rapidly at the (cid:494)plus(cid:495) end (cid:523)catastrophe(cid:524) Microtubule-organizing center-mtoc central site of mt assembly: dynamic instability. Non-motor: control mt organization in cytosol. Motor: two types (can power intracellular transport): Kinesin (plus end directed) and dynein (minus end directed: use atp to generate force, can move material along mt (cid:494)track(cid:495, can generate sliding force between mts. Contains a-helical domains: wrap around each other forming a coiled dimer. Monomers are aligned in parallel if dimers are polar. Assembly: g-actin polymerizes reversibly, nucleation (slow): Polymerization/depolymerization and structure/organization of f-actin filaments are regulated by actin-binding proteins: filaments can be lose or tight. Myosin is a motor protein associated with it: large family of proteins, most move its toward + end, divide into 2 groups: Generate force and contribute to mobility in non-muscle cells.

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