PHAR 100 Final: Module 5 Flashcards

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Jeanne Mulder, William Racz

Document Summary

Ehrlich introduced the concept of chemotherapy & provided a cure for syphilis. Florey & chain isolated penicillin for administration to patients. 4 pros of antibiotic combinations: unnecessary additional cost, increased chance of toxicity, increased chance of resistance, decreased number of normal bacteria strains fighting dangerous bacteria could cause superinfection. 8 steps of viral replication that can be blocked by antiviral drugs retrovirus replicates through reverse infectious agent that transcription: viral rna is reverse-transcribed into. Dna: viral dna is integrated into host. Dna: combined dna used to make both normal and viral proteins. Viral integrase mediated rna integration into host cell viral reverse-transcription pharmacological targets for. Drugs may be used prophylactically when exposed & at risk. Drugs may be used to prevent transmission to baby during pregnancy. 4 goals of chemotherapy: benefit/risk assessment, mechanism of action, adverse effects, dose & schedule, combination chemotherapy.