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Chemistry
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28 Nov 2019

Which one of the following statements concerning the citric acid cycle is correct?

A. The cycle produces three moles of NADH and one mole of FADH2 per mole of acetyl CoA oxidized to CO2 and H2O

B. The cycle is inhibited by malate.

C. Elevated levels of NADH stimulate oxidation of acetyl CoA by the cycle.

D. The oxidation of acetate leads to a net consumption (loss) of oxaloacetate.

E. The conversion of one mole of isocitrate to one mole of succinate results in the formation of five moles of ATP (including those obtained from oxidative phosphorylation).

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Related questions


5. Almost all of the oxygen (O2) one consumes in breathing is converted to: a. acetyl-CoA. b. carbon dioxide (CO2). c. carbon monoxide and then to carbon dioxide. d. none of the above. e. water.

6. A new compound isolated from mitochondria is claimed to represent a previously unrecognized carrier in the electron transfer chain. It is given the name coenzyme Z. Which line of evidence do you feel is the least conclusive in assigning this compound a position in the electron transfer chain? a. Alternate oxidation and reduction of the mitochondrion-bound coenzyme Z can be readily demonstrated. b. Removal of coenzyme Z from the mitochondria results in a decreased rate of oxygen consumption. c. The rate of oxidation and reduction of mitochondrion-bound coenzyme is of the same order of magnitude as the overall rate of electron transfer in mitochondria as measured by oxygen consumption. d. The reduction potential of Z is between that of two compounds known to participate in the electron transport chain e. When added to a mitochondrial suspension, coenzyme Z is taken up very rapidly and specifically by the mitochondria.

7. Which of the following is not true of the citric acid cycle? a. All enzymes of the cycle are located in the cytoplasm, except succinate dehydrogenase, which is bound to the inner mitochondrial membrane. b. In the presence of malonate, one would expect succinate to accumulate. c. Oxaloacetate is used as a substrate but is not consumed in the cycle. d. Succinate dehydrogenase channels electrons directly into the electron transfer chain. e. The condensing enzyme is subject to allosteric regulation by ATP and NADH.

8. Conversion of 1 mol of acetyl-CoA to 2 mol of CO2 and CoA via the citric acid cycle results in the net production of: a. 1 mol of citrate. b. 1 mol of FADH2. c. 1 mol of NADH. d. 1 mol of oxaloacetate. e. 7 mol of ATP.

1. Oxygen atoms present in CO2 that is released in the Kreb's cyclecome from-

a. Molecular oxygen (O2)
b. Acetyl CoA
c. H2O
d. Acetyl CoA and H2O
e. NADH + H+

2. How many ATP are obtained by substrate-level phosphorylationduring a complete oxidation of a single glucose molecule (includeGlycolysis, PDH reaction and the Krebs' cycle, do NOT subtract"energy investment")

a. 1
b. 2
c. 4
d. 6
e. 32

3. One of the differences between the isocitrate dehydrogenasereaction and the alpha-ketoglutarate dehydrogenase reactionis:

a. only one of them is an oxidative decarboxylation reaction
b. only one of them uses CoA-SH as the source for one electron(hydrogen)
c. only one of them uses NAD+ as the electron (hydrogen)carrier
d. only one of them requires ATP
e. only one of them yields ATP (or GTP)

4. Which of the following would most likely act as an inhibitor ofthe enzymes of the citric acid cycle?

a. high concentration of ADP
b. high concentration of ATP
c. high concentration of NADH
d. high concentration of NAD+
e. more than one of the above

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