An unknown mixture was analyzed using TLC on a silica gel plate and developed in 1:6 ethyl acetate:hexane, and gave 2 spots with Rf values of 0.6 and 0.5 respectively. 1)Would this be considered a good separation between the two? Briefly explain. 2)Which spot represents the more polar compound(s)? 3)Can you say for sure how many compounds are contained in the mixture? If so, how many are there? Briefly explain. 4)If not, what further conditions might be performed to determine the number of components in the mixture or to obtain a better separation? Explain. 5)Suppose you carry out a TLC separation of acetaminophen and aspirin on silica gel using a nonpolar eluting solvent, hexane. Which should have the larger Rf value? Briefly explain. 6)What are the methods for "visualizing" spots on TLC plates that we will use in this lab?
An unknown mixture was analyzed using TLC on a silica gel plate and developed in 1:6 ethyl acetate:hexane, and gave 2 spots with Rf values of 0.6 and 0.5 respectively. 1)Would this be considered a good separation between the two? Briefly explain. 2)Which spot represents the more polar compound(s)? 3)Can you say for sure how many compounds are contained in the mixture? If so, how many are there? Briefly explain. 4)If not, what further conditions might be performed to determine the number of components in the mixture or to obtain a better separation? Explain. 5)Suppose you carry out a TLC separation of acetaminophen and aspirin on silica gel using a nonpolar eluting solvent, hexane. Which should have the larger Rf value? Briefly explain. 6)What are the methods for "visualizing" spots on TLC plates that we will use in this lab?
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