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watching
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11 Nov 2019
3. The side-chain group on glutamic acid was found in the interior of a protein. For the function of this protein, it is speculated that the carboxylic acid group must be in the conjugate base form for activity. (i.e. must be negatively-charged) However, the pKR for glutamic acid is different at this site (pKa= 5.4) than on the free amino acid. Also the pH at this site is 5.0. Using the HH equation determine the % of the conjugate base form at pH 5.0 and decide if it is reasonable to expect the side-chain group to be predominantly in the conjugate base form at this pH. 4 Dofine motif and aive three avemnlos
3. The side-chain group on glutamic acid was found in the interior of a protein. For the function of this protein, it is speculated that the carboxylic acid group must be in the conjugate base form for activity. (i.e. must be negatively-charged) However, the pKR for glutamic acid is different at this site (pKa= 5.4) than on the free amino acid. Also the pH at this site is 5.0. Using the HH equation determine the % of the conjugate base form at pH 5.0 and decide if it is reasonable to expect the side-chain group to be predominantly in the conjugate base form at this pH. 4 Dofine motif and aive three avemnlos
Irving HeathcoteLv2
15 May 2019