All amino acids have two ionizable functional groups: an α-amino group (average pKa of 9.4) and an a-carboxylic acid group (average pKa of 2.2). Tyrosine also has an ionizable side chain (R group) with a pKa of -10.1. One of the possible ionization states of tyrosine is shown below. H3N CH -C OH CH2 OH At what pH would the structure above be the predominant ionization state? Note: Consider the ionization state of all three of the functional groups. pHSelect answer Scroll down for more of this question. The protonated form of the R group of tyrosine is shown in the structure above. The ratio of the protonated form to the charged (deprotonated) form depends on the pKa of the R group and the pH of the solution. Select the pH value at which the charged form of the R group would predominate.