Lecture : Hardy Weinberg Law
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Hardy-weinberg assumption: individuals must randomly mate, no migration (no gene flow, no mutation, genes are autosomal, no selection, population must be very large. Hardy weinberg theorem or hardy weinberg law p2 +2pq +q2 = 1 (a = p, a = q, p+q = 1) Frequency of a = p: frequency of homozygous dominant (aa)=p2. Frequency of a = q: frequency of homozygous recessive aa=q2. The frequency of different genotype produced due to random mating will depend upon the gene frequency and equilibrium is stablished after one single generation of random mating. Note: changes in allele frequency are the genetic basis of evolution: in a random large population frequency of recessive phenotype is 0. 36. What is the frequency of heterozygous genotype? q2 = 0. 36 q = 0. 6 p = 1 q p = 1 0. 6. =48: in the caucasian population of the us, 1 in 2500 babies is affected by a recessive condition cystic fibrosis.
