HMB265H1 Lecture Notes - Lecture 10: Monte Carlo Method, Allele Frequency, Genetic Linkage

• School: UTSG
• Department: Human Biology
• Course: HMB265H1
• Professor: Maria Papaconstantinou

Document Summary

There are questions about the genetic composition of populations that can"t be answered fully by knowledge of individual genetic processes. Lecture 10 outline: hardy-weinberg equilibrium, hardy-weinberg calculations, genetic drift, natural selection, mutation, application of population genetics. E. g. , phenylketonuria (pku) is a heritable metabolic disorder, and an autosomal recessive trait. Proportion of individuals in a population that express a particular phenotype. 1862 1937: random mating resulted in an equilibrium distribution of genotypes. This equilibrium distribution is known as the hwe. The hardy-weinberg law correlates allele and genotype frequencies. If certain assumptions were met, allele frequencies, genotype frequencies, and phenotype frequencies would remain constant over time and between generations. The hardy-weinberg law clarifies the relation between genotype and allele frequency within a generation and from one generation to the next. Five assumptions must be met for a population to be at. Hardy-weinberg equilibrium: no genetic drift, no inbreeding, no new mutations, no gene flow, no natural selection.