BIOCHEMISTRY Lecture Notes - Lecture 1: Nicotinamide Adenine Dinucleotide Phosphate, Nicotinamide, Pellagra

• School: Kerala University of Health Sciences - KUHS
• Department: Biochemistry
• Course: BIOCHEMISTRY

Document Summary

It is also called as pellagra preventing factor of goldberger. Nicotinic acid is a vitamin; but, nicotine is the potent poison from tobacco. Niacinamide is the active form of the vitamin, present in tissues. The coenzyme forms are nicotinamide adenine dinucleotide (nad+ ) and. The nitrogen atom of niacinamide contains one positive charge. The structure is abbreviated as nad+ . (the +ve sign is always shown). In the case of nadp+ , one more phosphoric acid is attached to the ribose of the amp. Deficiency of niacin leads to the clinical condition called pellagra. Dermatitis: in early stages, bright red erythema occurs, especially in the feet, ankles and face. Increased pigmentation around the neck is known as casal"s necklace. Diarrhea: the diarrhea may be mild or severe with blood and mucus. Dementia: it is frequently seen in chronic cases. Irritability, inability to concentrate and poor memory are more common in mild cases.