CSB329H1 Lecture Notes - Asymmetric Cell Division, Spermatogenesis, Gonad
Document Summary
C elegans is a model organism because small simple anatomy, cheap, short life cycl;e, hermaphrodite (has male and female germline making the genetics simpler). Invariant cell lineage has been traced from cell embryo to all cells in the adult. Germline stem cells are a source of continuous production of gametes with ability to produce differentiated daughter cell and daughter stem cell through asymmetric cell division. A more differentiated daught ccell germ cell continues to differentiate and undergoes meiosis to produce mature gametes. Mitotic germ cells (earlier version of germ line stem cells) and somatic gonad cells (structural) Cells closer to uterus are meiotic germ cells (mature sperm by end of l4). End of l4 stage looks like a mature gonad with u shapes arms. Closer to uterus are cells which commit to sperm development. Distal tip are germ line stem cells and continue on to differentiate into oocytes. Distal cells switch from sperm to making oocytes.
