PHRM 100 Lecture 7: PDD 7
Document Summary
Mixtures of two or more components that form a homogenous molecular dispersion one-phase. Solutes are < 1nm in diameter and not large enough to scatter light. A dispersion containing particles between 1 500 nm in diameter. Particles scatter light and may appear visibly turbid (depending on [drug] = tyndall effect) Lyophilic: particles have affinity for dispersion medium. Lyophobic: particles lack affinity for dispersion medium. Association colloids: self- association of amphiphilic solutes that form into a colloid above a certain concentration( i. e micelle forms above cmc) A dispersion with particles >500 nm in diameter. Particles scatter light and appear visibly cloudy. Solid in liquid coarse dispersion is a suspension and liquid in liquid coarse dispersion is an emulsion (oral) pharmaceutical solutions: Easily administered orally to individuals who have difficulty swallowing compared to tablets, capsules. Drug is already dissolved in the formulation immediately available for and absorption, enhanced bioavailability over oral solid dosage forms potentially therefore.
