BIOL 3225 Lecture Notes - Lecture 6: Globular Protein, Immunoglobulin Light Chain, Troponin

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24 Oct 2021

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Made of about 200 or more myosin molecules. Body- twisted heavy chains which forms a very long and rigid and insoluble tail( providing structure) Cross- bridge- two globular heads- come as a result of these light chains of your myosin molecules that attach to the heavy chain. Where you find an actin site and atp component. Hinge- flexible region of your myosin molecule that allows for the cross bridge to move towards the actin. Actin- the structural protein component( get a whole bunch of g actin(globular protein) and they come together and make f actin) To control actin and myosin interactions by being a calcium sensitive protein that binds to tropomyosin protein. Wrapped around the actin in such a way that it blocks those cross bridge binding sites. A band( where you find myosin or actin) I band (thin filament only) bisected and anchored by z line.

Related Questions

Put the events of a single cross-bridge cycle in the properorder. Start with Calcium is released from the sarcoplasmicreticulum.

a) myosin binds to actin

b) ATP binds to myosin, cross-bridge disconnect

c) ATP splits into ADP and Pi

d) Myosin head re-energized, repositions into high energystate

e) Calcium resequestered into sarcoplasmic reticulum

f) Cross-bridge power stroke

g) Calcium binds to troponin , and actin binding sites areexposed

Determine whether each of these statements is true or false and then explain why?

a) Myosin II molecules have two motor domains and a rodlike tail that allows them to assemble into thick filaments with motor domains on either end, which is crucial for the efficient sliding of oppositely oriented actin filaments past each other.

b) When activated by Ca2+ binding, troponin C causes a conformation change in the troponin complex that allows tropomyosin molecules to shift their positions slightly so that the myosin heads can bind to the actin filaments.

c) In most animal cells, minus-end directed microtubule motors deliver their cargo to the periphery of the cell, whereas plus-end directed microtubule motors deliver their cargo to the interior of the cell. (Be sure to name these motors).

d) Both kinesin-1 and myosin II move processively making them suitably adapted for their biological functions.

e) Axonemal dyneins mediate the bending of cilia and eukaryotic flagella.

The following proteins are all members of a class of proteinsbind to the side of microtubules.They have different functions, some stabilize and some destabilizemicrotubles.

Capz

tau

XMAP215

MAP2

cofilin

KINESIN 13

tropomyosin

The following accessory protein binds to tubulin dimers and is analogous in function to thymosin.

cofilin

profilin

kinesin-13

stathmin

The following protein binds to the side of actin filaments and stabilizes it through interaction with sevenactin molecules.

cofilin

tropomyosin

thymosin

profilin

The following severing protein binds to microtubules and can both promote assembly of new polymersand promote disassembly of oldpolymers.

gelsolin

katanin

MAP2

TAU

The following protein binds to the side of actin filaments and destabilizes them by twisting thefilament and weakining the contacts between the actin molecules.

		cofilin
		profilin
		Arp
		tropomyosin

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BIOL 3225 Lecture Notes - Lecture 6: Globular Protein, Immunoglobulin Light Chain, Troponin

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