BIO 1140 Lecture Notes - Lecture 12: Earl Wilbur Sutherland Jr., Quorum Sensing, Signal Transduction
Document Summary
1971 nobel prize for his discoveries concerning the mechanisms of the action of hormones . Three stages of cell signalling - an overview: reception. The target cell detects a signalling molecule that bonds to a receptor (often at the cell surface: transduction. Reception of signal causes receptor to initiate a signal transduction pathway (usually a series of steps: response. The transduced signal triggers a specific response in the target cell. Cell signalling is critical in the microbial world. The relative concentration of signalling molecules allows bacteria to sense local population density. In politics and business, a quorum is the minimum number of members required to be present to vote on an issue. In bacteria, population density is often the key factor for signalling.
