HLTH 230b Lecture Notes - Lecture 3: Interferon Gamma, Granuloma, Phagosome

• School: Yale University
• Department: Global Health Studies
• Course: HLTH 230b
• Professor: Kristina Talbert- Slagle

Document Summary

Mycobacterium bacterial infection: (cid:862)o(cid:271)ligate i(cid:374)ter(cid:272)ellular parasite(cid:863, divide on their own, own dna. In humans, first confirmed source of dna found in samples about 8000-9000 years old at prehistoric site in israel: carried in airborne particles (droplet nuclei) of 1-5 microns in diameter. Infectious droplet nuclei are generated when persons who have pulmonary or laryngeal tb disease cough, sneeze, shout, or sing: tb can occur in pulmonary and extrapulmonary sites. Interferon gamma response assay (igra): tb diagnostic test: specificity: how often negative test gives accurate negative result, +/+ sensitivity, +/- false positive, -/+ false negative. /- specificity: about 2 billion living with ltbi, 5-10% of latent become active, hiv causes increase of latent to active by 5-10 fold, about 9. 2 million new cases of active tb per year, 1. 4 million deaths per year. Tb skin test: delayed-type hypersensitivity reaction (vs. immediate: th cells that react against tb.