NURS 364 Lecture Notes - Lecture 17: Lactic Acidosis, Cellular Adaptation, Metaplasia
14 Dec 2017
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Document Summary
Either because of the injury itself or the repair process that follows. Allows the stressed tissue to survive or maintain function. Metabolic processes shut down to conserve energy. Lack of nutrients lack of nerve or hormonal stimulation. One cell type to another cell type. Most common causes of cell injury: hypoxia / ischemia. Lactic acidosis: generation of reactive oxygen species/free radicals. Oxidative stress: chemical injury, hypoxia ischemia mechanism, hypoxia ischemia mechanism. Cell usually maintains low intracellular calcium: hypoxia ischemia mechanism. Hypoxic injury: reactive oxygen species (free radical injury) Molecules with an unpaired electron in the outer orbit (valence shell) Ros are a product of the mitochondrial respiration. Normally removed from the body by antioxidants. Oxidative stress occurs when the generation of oxidative free radicals exceeds that ability of the body to eliminate or neutralize them: reactive oxygen species (free radical injury) Can react with normal cell components: protein, lipids & carbohydrates.
