BSCI-1510 Lecture Notes - Lecture 14: Secretion, N-Terminus, Cell Membrane
10 Feb 2016
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Document Summary
Chloroplast and mitochondria have their own genome but very few genes are coded by those genomes. Localization signal found in amino terminus of that protein. Gated transport is used by nucleus and peroxisome. Polypeptide chain in its unfolded state is threaded through a small hole in membrane in the mitochondria, chloroplast and er (translocation) Targeting signals are require for any proteins leaving the cytosol. Mitochondria ahs a few diferent types of targeting signals. Matrix targeting signal: takes a polypeptide across outer/inner membrane: all membranes of the tca cycle have this targeting signal. 3 inputs of energy: cytosolic hsp70 (atpase, proton gradient across the inner membrane, mthsp70 (atpase) Once protein bumps into mitochondria, there is a receptor collectively called the tom complex (translocation across outer membrane of mitochondria) Tom has to be coupled with tim complex (translocation across inner membrane of mitochondria) Polypeptide chain is threaded across both membranes into the lumen where matrix there is an enzyme that clicks of.
