BIO 346 Lecture Notes - Lecture 2: Cellular Differentiation, Methyl Group, Preformationism
Document Summary
Game plan: history of epigenetics, definition, molecular of transcription regulation. Mukerjee - same genetically identical (twins) different personalities, and traits (shaped by environment - epigenetics) epigenetics aristotle) Critiques: not the right origin of the term epigenetics (doesn"t come from. Also - tfs that seem to induce pluripotency (3 constitutive tfs) revert differentiate cells into an undifferentiated cell redifferentiation. Combine expression of certain set of tfs in whatever methylation state of its chromatin drive the modification of dna methylation and reversion to the unmethylated state. Epigenetics - origin of word - aristotle epigenesis . Competing ideas - how individuals, or species go from zygote (undifferentiated) Aristotle - process of becoming an adult/specialized form from an unspecialized. How organisms came to take their forms. Philosophical perspective - things that are already formed in the earliest minutes (preformation) look close enough at zygote you would see a tiny person already formed (ovists, spermists) We are already there in full potential at earliest stage.
