BIO 325 Lecture 11: Lecture 11 – Gene Expression
Lecture 11 – Gene Expression
Centro Dogma
• Transcription – by RNA Polymerse (DNA to RNA)
• Translation – by ribosome or tRNA (RNA to Protein)
• Central Dogma – the usual flow of genetic information within a cell or organism is often
alled the central dogma” of molecular biology
Genes
• Genes specify the amino acid sequency of a polypeptide
o Most phenotypes are due to changes in amino acid sequences
• Poteis ae sthesized eadig RNAs
o wods ae odos ad tRNAs ae adaptes etwee odos ad amino acids
• At ribosome, tRNAs guided by mRNA align amino acids for peptide bond formation
o
o RF = #rec/total x 100
Recombination Events Within Genes
• Bacteriophage T4
• Viuses popagate as plaues o a ateial law
• Phaques can have morphological phenotypes that depend on the phage and host
genotypes
• Phaque phenotypes
o Large – small = lysis speed
o Clear – cloudy = host range
Fine Structure Mapping of rII
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