PHSL 3061 Lecture Notes - Hyperinsulinemia, Insulin Resistance, Cardiovascular Disease
Document Summary
T2d significantly increases risk of heart attack, stroke, or death from cardiovascular (cv) 65yo with t2d, 65% of dying from cv. 2013, 25. 5% adults were obese, and 35. 6 % were overweight. 2012, 12. 7 % children 2-5 years of age enrolled in wic were obese. Diabetes is a chronic disease in which the body cannot regulate the amount of glucose in the blood (hyperglycemia). Immune-mediated loss of -cells leading to the progressive decrease in insulin production: type 2 diabetes. Defective adaptation or insulin production of -cells to insulin resistance. Dysregulation of insulin and glucagon leads to hyperglycemia in diabetes. Insufficient insulin and elevated glucagon secretion in diabetic patients. Alejandro et al, mol aspects med, 2014, prenki, jci, 2006. Natural history of the adaptation of -cells to diabetes. The number and proliferative rate o f pancreatic progenitors represent a critical and limiting determinant of. Cell mass and pancreas size (stanger et al, nature, 2007).
