PHYSL402 Lecture Notes - Lecture 3: Diabetes Mellitus Type 1, Cell Adhesion Molecule, Dementia

• School: University of Alberta
• Department: Physiology
• Course: PHYSL402
• Professor: Dr.shamza

Document Summary

402: lecture 3 insulin resistance and chronic diseases (jan 8/16) In diabetic, blood glucose will remain elevated for longer than normal (1-2hr) Reduced hdl cholesterol <1. 03 mmol/l (male) or <1. 29mmol/l (female) Define insulin resistance, metabolic syndrome (mets), type 2 diabetes (t2d) Compare prevalence of mets in developed and developing countries (adults and children) List adverse outcomes assoc with insulin resistance/mets (individuals and society) Must have central obesity (ethnic specific) or bmi > 30kg/m2 + two of the following. Ce(cid:374)tral o(cid:271)esity: a(cid:272)(cid:272)u(cid:373)ulatio(cid:374) of fat i(cid:374) a(cid:271)do(cid:373)e(cid:374) (cid:894)apple shaped(cid:895) (cid:448)s (cid:862)pear shaped(cid:863) (cid:894)thighs, ar(cid:373)s etc); central obesity = the problem (will be described soon) Bmi can be substituted if central obesity is not measured. In addition to central obesity, must have 2 of the 4 criteria. Hyperglycemia and glucose intolerance (inability to process ingested glucose) Type i: autoimmune: mainly hyperglycemia, but can have glucose intolerance. Insulin sensitivity will generally return to normal for gdm; but mom has higher risk of developing.