MICROBIO 310 Lecture Notes - Lecture 8: Autolysin, Agar Plate, Rela
23 Mar 2016
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Chapter 8-regulation of gene expression: control over the activity of pre-existing enzymes: posttranslational regulation, which is a very rapid process, control over the amount of enzyme: regulates level of transcription, translation slower process. Mrna transcripts generally have a short half life: prevents the production of unneeded proteins. Regulation of transcription typically requires proteins that can bind to dna. Small molecules influence the binding of regulatory proteins to dna: proteins actually regulate transcription. The first step in considering the biological information flow is transcription. Dna-binding proteins: interact with dna in a sequence specific manner. Interactions between amino acid side chains and chemical groups on the bases and sugar phosphate backbone of dna. Major groove: site of protein binding in dna. Inverted repeats: frequently the binding site for regulatory proteins. Homodimeric proteins: proteins composed of two identical polypeptides. Protein dimers interact with inverted repeats on dna each polypeptide binds to one inverted repeat.
