MCDB 423 Lecture Notes - Lecture 25: Salivary Gland, Caspase, Cytochrome C

• School: U of M
• Department: Molecular, Cellular and Developmental Biology
• Course: MCDB 423
• Professor: John Kuwada

Document Summary

Neurotrophins are growth factors and inhibitors of cell death. Ne(cid:272)rosis: the (cid:272)ell lost the io(cid:374)i(cid:272) (cid:271)ala(cid:374)(cid:272)e a(cid:272)ross it"s (cid:373)e(cid:373)(cid:271)ra(cid:374)e a(cid:374)d the (cid:373)e(cid:373)(cid:271)ra(cid:374)e has ruptured. Apoptosis: the cell is dying; membrane is intact and is becoming fragmented from the inside. Death of neurons and cells are usually programmed. Have upstream regulators (factors that prevent an activate it) You also need to regualt the caspases slide 4. Caspases are made in an inactive form (made with a prodomain) The activate caspase requires removing of the prodomain and cleavage of an internal site which would allow the two parts to come together in a new conformation to make an active caspase. Caspase 9 interacts with apaf1 and cytochrome c. Cytochrome c is needed to activate caspase 9. Cytochrome c is a component of the mitochodrina (in the inner matrix) So the cytochrome c has to to exit the mitochodria to activate the caspase.