MCDB 423 Lecture Notes - Lecture 28: Organelle, Motor Neuron, Calpain

• School: U of M
• Department: Molecular, Cellular and Developmental Biology
• Course: MCDB 423
• Professor: John Kuwada

Document Summary

All of our cells have this apoptosis machinery. Can lose neurons in an unwanted fashion by activating this mechanism or by losing control of metabolic pathways. Apoptosis is a program which has signaling molecules that happens in the cell. Neurotrophin signaling by binding to a neurotrophin receptor is triggering downstream signaling including. Transcriptional responses that can stimulate transcription of anti-apoptic factor such as bcl2. Not having neurotrophin signaling would be a bad thing for the maintaince of your neurons in the brain. We also saw that target derived neurotrophins is important for inhibiting apoptosis. In the chick, there are target derived neurotrophins secreted from the developing muscles from the limp buds. One thing one can do to study signaling within axons specifically from cell bodies is to culture neurons in compartmentalized chambers which will allow you to expose axons and cell bodies to different manipulative environments. The classic name for these chambers is called a campenot chamber.