MCDB 423 Lecture Notes - Lecture 29: Fibril, Lysosome, Scrapie

• School: U of M
• Department: Molecular, Cellular and Developmental Biology
• Course: MCDB 423
• Professor: John Kuwada

Document Summary

The five points mentioned in the slide slide 3. These are brain sections that have several different diseases. There are large plaques (ameyloids) which contain aggregates of abeta pepitde. Also tangles of proteins called tau slide 5. He(cid:396)e"s a(cid:374) e(cid:454)a(cid:373)ple of a (cid:271)(cid:396)ai(cid:374) f(cid:396)o(cid:373) a health(cid:455) i(cid:374)di(cid:448)idual. B(cid:455) the ti(cid:373)e a pe(cid:396)so(cid:374) has passed a(cid:449)a(cid:455), the(cid:396)e"s (cid:373)assi(cid:448)e loss of (cid:373)ultiple (cid:272)ells i(cid:374) (cid:373)ultiple areas of the (cid:271)(cid:396)ai(cid:374) i(cid:374) a(cid:374) alzhei(cid:373)e(cid:396)"s patie(cid:374)t. Some areas in the hippocampus are the first areas to go. Spreads to take over multiple parts of the brain. This is seen in many diseases similar to alz. The(cid:396)e a(cid:396)e i(cid:374)sta(cid:374)(cid:272)es (cid:449)he(cid:396)e (cid:449)e do(cid:374)"t k(cid:374)o(cid:449) if the(cid:396)e a(cid:396)e genetic components and why the disease arose. From the familial forms, inherited mutations in the abeta precursor protein called app is a common form of the familial alz. Also mutations in psen1 and psen2 are comon slide 6. This is a simple cartoon of the abeta precursor protein (blue structure)