BIOLOGY 305 Lecture Notes - Lecture 6: Intermediate 1, Bad Copy, Sickle-Cell Disease
Document Summary
He came up with the theory that genes controlled enzymes. Studied metabolic pathways in neurospora and showed that a metabolic pathway was controlled by a different enzyme for each part of the pathway. When you see complementation, the genes (mutations) are on different chromosomes. Suppressors are new mutants that reverse effect of other mutant. A fix involves 1 gene and a suppressor involves 2 genes. -if revertant, fixed mut1 x wild-type = all wild type. -if suppressor, mut1/mut2 x wild-type = mix of wild type and mut1 pheno (typically 13:3 or 14:2 ratio wt:mut1) Suppressor mutation on its own may or may not have a phenotype. Generally means wild-type versions of mut1 and mut2 gene products interact in some way. Molecular model for suppression (figure 6. 19) (genetic test) Today we will be talking about gene interaction. Phenotype is determined by more than one locus (genes) This is when multiple traits are attributable to a single gene.
