BCHS 3304 Lecture Notes - Lecture 21: Cytochrome P450, Glycogen Phosphorylase, Lead Compound
17 Nov 2016
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Control by covalent modification: phosphorylation= adding a phosphate group to the oh group of. Lecture 21 like a ser, thr, or tyr. Protein kinase: kinase is a type of transferase, addition of a phosphate group can activate the enzyme. Takes it from the t state r state. Can be removed by a protein phosphatase. Phosphatase is a type of hydrolase: accompanied by addition of water. Glycogen (n residues) + pi glycogen (n-1 residues) + g1p: g1p is glucose 1 phosphate. T r: the n terminal is moved to the surface in the. R state: the active site of the enzyme is made more available in the r state, remainder of structure is more or less retained. R form t form: via atp or g6p. T form + 2 atp r form. Drug design: design is based on structure and chemistry, bioavailability: determined by how drug interacts with the body. The way that the drug passes through the gi tract.
