CBIO 3400 Lecture Notes - Lecture 38: Pleckstrin Homology Domain, Protein Kinase C, Protein Kinase B
22 Apr 2016
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Document Summary
Activates a series of kinases called map kinases. And these kinases start changes in proteins and gene expression. Map kinase signals produce long-term and short-term affects. Makes decisions about whether cells should survive, grow, or die. Ras and raf work together to stimulate proliferation of cells inhibiting this pathway (anti-cancer drugs) could hurt the rest of your body like stem cells, stomach cells, and hair cells. Signaling complexes assemble (before or after receptor activation) Scaffolds can have multiple domains that recognize specific proteins. I. e: raf, mek, and erk are all on the same scaffold protein which allows for a downstream signal, activating each protein. Signaling complex can also be assembled on the activated receptor directly does not need separate scaffold protein. Proximity is important, but not enough to ensure specificity. Activation of phospholipase c (done by g protein or protein scaffold) (plc beta or gamma) Dag plus calcium activates protein kinase c (pkc) which leads to cell growth.
