CBIO 3400 Lecture Notes - Lecture 37: Sh2 Domain, Proline, Cell Signaling
20 Apr 2016
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Protein in signaling pathways have specific domains that recognize features. **when a protein is phosphorylated and undergoes a conformational change-> the protein will now display a part of the protein that was covered (i. e proline rich regions in sh3) and signals to other proteins. Domains are distinctly folded parts of proteins that can be separated from the protein and retain their structure. Proteins in signaling pathways often contain multiple domains like this. Example: protein kinases will have kinase domains with enzymatic activity coupled with a recognition domain like an sh2 kinase. If you removed the sh2 kinase, it would no longer be dependent on an outside signal, and would turn into cancer. **90% of mutation that lead to cancer happen in signaling pathways. Src homology 2 (sh2) domains bind phosphorylated tyrosine (ptyr) Sh2 domains recognize ptyr in context of target peptide. Sh2 binds target only if tyrosine is phosphohrylated.
