BSC 2010 Lecture Notes - Lecture 6: Dna Replication, Nucleic Acid Double Helix, Crystallography
25 Mar 2015
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Bsc2010: integrative principle biology i-lecture #6:search for dna, replication, and. Inheritance of trusts focusing on the informational macromolecules. Ribose vs deoxyribose: at the second space (look at the sugar:distinguishing factor) Cytosine and guanine form stronger bond because there"s 3 hydrogen bonds. Each new dna strand grows by the addition of nucleotides to its 3" end because it grows. Three different lines of evidence: 1) chargaffs rule {a}= {t}; x-ray diffraction; physical chemistry model. Central dogma (in order: replication to post translational processing) Semiconservative dna replication: complementary strands stands as a template for the new strand. There will be both leading and lagging strands in dna synthesis. 5" atgcagcttt 3" dna; after rna synthesis it should look like 3" uacgucgaaa 5" Dna polymerase: the enzyme for the synthesis of new dna chains. Nuclease: enzyme that breaks down a nucleic acid. Endonuclease: introduces internal cuts or fragments nucleic acids.
