PSYC414 Lecture Notes - Lecture 13: Lipophilicity, Caudate Nucleus, Phospholipid

• School: University of Delaware
• Department: Psychology
• Course: PSYC414
• Professor: Jeffery Rosen

Document Summary

Cycle of pathological drug use that can lead to the development of addiction. Starts off as taking it for fun/experimenting becomes a compulsion; withdrawal, binging, etc. Dopamine: main pathways for dopamine for addiction are from the vta (mesolimbic and mesocortical) Mesolimbic: main target is nucleus accumbens: a part of basal ganglia; involved in local motor activity, learning and memory/reward, aversive affects, Giving a little bit of psychostimulant to animal move around a lot; prefrontal cortex receives dopamine as well (control mesolimbic system activity) Striatum (substantia niagra) projects up to caudate putamen (occurs later in addiction; more compulsion) Pfc_ inhibition control, executive function, mesocortical da. Amg- learning, associating specific and contextual cues w/ rewards and punishments (connecting outside stimuli in environment w/ rewarding and aversive stimuli) Insula cortex- subjective (euphoric/reinforcing?) effects of drugs: getting info from the body to understand how we feel about things. Incentive-sensitization model of addiction next time we see something, we have same response (memory)