PCL201H1 Lecture Notes - Lecture 31: Caffeine, Reuptake, Dopamine Receptor

• School: UTSG
• Department: Pharmacology and Toxicology
• Course: PCL201H1
• Professor: all

Document Summary

Lecture 31 reward and pharmacology of drug misuse: some important terms, theories of addiction and misuse, dopamine theory of reward, physical dependence and tolerance, substances commonly misused, nicotine, opiates, cocaine. Rate of drug-related deaths are increasing: some important terms. Problematic substance use: maladaptive pattern of use leading to impairment or distress: non-medical use, not (cid:862)depe(cid:374)de(cid:374)cy(cid:863) Spectrum of psychoactive substance use: beneficial casual/non-problematic problematic. Some drugs are initially prescribed as a therapeutic, but later misused (opioids, narcotics) Others are exposed to in a recreational setting. Addiction: chronic relapse disorder in drug-seeking behaviours: physical and psychological dependence, physical and social harm, craving/relapse cycle, fasting onset drugs have a faster reinforcing effect, all activate the reward pathway, theories of addiction and misuse. Maladaptive learning (ltp and ltd: physical dependence. Pk (changes in receptor or signal cascade) Cross tolerance (tolerance of one drug affects another)