PCL201H1 Lecture Notes - Lecture 17: Methadone, Analgesic, Cannabinoid Receptor Type 1
11 Jan 2018
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Document Summary
Substance use disorder: mesolimbic dopamine reward system, dependence: tolerance, withdrawal. Problematic drug use (prescribed initially, misuse: maladaptive pattern of use. Chronic dependence, disorder: craving/relapse (addiction) cycle, determined by route and drug effects, factors include genetics, environment, behavioural cues, dependence, reward pathway. Da system: increasing dopamine inappropriately, from vta to nucleus accumbens, inactive gaba (disinhibition, activate glutamate (da or glu, prevent reuptake into da. Dependence: tolerance and withdrawal, increasing dose, avoiding withdrawal and negative effects, shift dose-response curve right, metabolic tolerance: inducing dme (ie. nicotine, alcohol, phenytoin at p450), do not alter drug concentration at site of action. How to study: in animals, genetic models, in vitro, in vivo, ex vivo. Common substances: nicotine: highest addiction risk, high dependence: nicotine, heroin, high da system: heroin, cocaine, alcohol, intoxifying: alcohol, heroin, cocaine. Nicotine: ach receptors (increase release, lipid, results in reward system and dependence.
