PSYC414 Lecture Notes - Lecture 7: Autonomic Nervous System, Catechol, Mesocortical Pathway
27 Feb 2018
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Controls membrane potentials; enough action potential. Inhibitory postsynaptic potentials: cl- negatively charged sitting on the outside; makes it hyperpolarized; more negative. Potassiu(cid:373) is(cid:374)"t (cid:272)o(cid:374)trolled as (cid:373)u(cid:272)h (cid:271)y the nt / liga(cid:374)ds that (cid:271)i(cid:374)d to it, (cid:271)ut it is (cid:272)o(cid:374)trolled by the metabotropic ones. Transmembrane domains: g coupled protein receptors (gpcr) Binding in the pocket on the outside of the cell; on the inside, the confirmation changes allowing for the binding of g protein. Nt drug binds to the receptor, it then can effect the g protein; the g protein then can affect (for example) a g protein gaited ion channel (potassium ones; controlled internally through this system) G proteins change the confirmation of that channel, allowing potassium (on the inside) to flow to the outside; this hyperpolarizes the cell. A lot of second messengers made from atp: then binds to protein kinase; this changes its shape or activates it; then has cellular effects: kinase- phosphorylates proteins.
